Spermatogenesis
Physiology of the male reproductive system
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I). Spermatogenesis
1). walls of the seminiferous tubes continuously dividing
2). The outer layer of cells divide into:
Basement membrane cells
Primary spermatocytes
Spermatogenesis
Meiosis I results in
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spermatocyte spermatocyte
Meiosis II results in
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Spermatid Spermatid Spermatid Spermatid
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each spermatid now most undergo
Spermiogenesis
(development of motility)
II). Spermiogenesis
A). Sperm learn to swim
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B). Regions of the sperm
1). Genetic Region: Head
acrosome a lysosome-like structure
2). Metabolic Region: Midpiece
Contains mitochondria
3). Locomotor: Tail
III). Sustentacular Cells
A). From Blood-Testes Barrier
Prevents the antigen from the sperm entering the blood stream
B). Move the sperm into the lumen
C). Supply transport medium
IV). How long does Spermatogenesis take?
V). Hormonal Control of Spermatogenesis and Testosterone Production
(Brain-Testicular Axis)
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A). Mechanism
1). Hypothalamus
(GnRH)
2) Anterior Pituitary
)(LH) (FSH
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3). Testes
i). LH
Testosterone (Androgen)Þ
enlargement of the testes secondary sex characteristics deepening voice thickening skin enlargement of the muscles ii). FSH
bind testosterone Þ
stimulating spermatogenesis
B). Feedback mechanisms
1). Testosterone inhibits GnRH
2). Testosterone inhibits FSH & LH
3). Inhibin inhibits FSH and GnRH