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Human Development

Lecture

 

Development divides into

First trimester

Zygote

Embryo

Second trimester

Fetus

Third Trimester

      

I). Fertilization

A). How long are the sperm and secondary oocyte viable?

oocyte: only 12 to 24

sperm: 72 hours

The fertile period for a woman is 3 days before ovulation and 24 hours after.

 

B). Success of the sperm depends on.

bulletnever make it to the cervix
bulletdestroyed by the acidic environment of the vaginal tract
bulletblocked by the mucous of the cervix
bulletdestroyed by lymphocytes

 

C). What prevents polyspermy?

Step 1.  Contact with sperm opens Na+ channels.  Membrane depolarizes

Step 2.  Ca2+ is release

i. Readies for cell division

ii. cortical reaction.  Destroys  sperm receptors

iii.  Bind with water swelling the membrane

II.  Implantation

Blastocyst befins to implant Blastocyst continues to implant
7-10 days after implantation begins

 

blastocyst tries to implant high in the uterus

regulatory hormones prepare the uterus

trophoblast cells adhere to the endometrium

digests the uterine cells

blastocyst covered with uterine lining

corpus luteum maintains the uterine wall for 2 weeks after ovulation

The trophoblast cells of the blastocyst release human chrorionic gonadotropin (hCG) which acts like luteinizing hormone.

The embryo now takes over control of the uterus.

At the second month the placenta takes over the hormone role.

 

III.  Formation of germ layers

Germ layers

ectoderm

endoderm

mesoderm

 

 

Embryonic Folding

Embryo starts as a flat disc

of 3 germ layers

È

Folds laterally into a tube

È

both ends fold into the center

È

edges come together and fuse

 

Embroynic folding

 

IV). How do structures originate? (organogenesis)

1). Ectoderm

Neurulation:

 

Neurulation
Neuralation

Notochord

È

neural plate

È

neural groove

È

neural folds

È

neural tube

È

pinches off:

anterior-forms brain

posterior-spinal cord

È

associated cells give rise to peripheral ganglia

 

2). Endoderm Specialization

forms  epithelial linings

 ends fuse the endoderm forms the gastrointestinal tract

È

Pharynx, esophagus, stomach, intestine form

È

oral and anal openings perforate

 

3).  Mesoderm

 divides into

Somite:

sclerotome

dermatome

myotome

Intermediate mesoderm:

Lateral mesoderm:

 

Connective tissue formed by the mesosderm

V).  embryonic development

 

Embryonic DevelopmentEmbryonic Development
EmbryoEmbryo

 

VI.  Fetal Development